Lyric discussion by namelessmusician1 

Whoever said Karen is a drug does not know the national very well...Matt Berninger (the lead singer) married to a woman named Carin, and all references to Karen are pretty obviously references to her. Actually anyone who thinks they're making drug references in any song is probably wrong. "Good Mixture" almost certainly means a good mixed drink, the national make constant and obvious allusions to alcohol (in like every other song), and basically never talk about drugs.

Yeah, I've seen a few comments on a lot of songs claiming drug references, but the only song I can think of that has any is "Friend of Mine." There has to be others, but Matt Berninger's just a poet. His descriptions of things are often abstract, some almost stream of consciousness and others surrealist. It's a fair enough assumption by some though since a lot of songwriters just throw in a shit ton of references into their songs and we're kind of surrounded by them day to day.

When he's says "Good Mixture" I think he's talking about being in a good mental state, good brain chemistry.

I like to think it's like a multi-layered metaphor. You can understand the drug aspect, and then you can translate that to how he feels and what he's feeling it about.

In the end, I feel it's just another creative way of saying what he's already said in that verse - "now I'm here, now I have something going, how do I make this moment, this opportunity into something great? Shit, I don't know".

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