Lyric discussion by JohnApricot 

I think this song is pretty obviously about cocaine. I also think it's not really just about use cocaine considering, as mackka pointed out, Nick Cave doesn't really write songs that are just about how much drugs suck. I think that the biblical referencing with the names relates to a loss of faith due to the drug use, and the isolation mackka pointed out is literal isolation due to friends dying, paranoia from the drug, and spiritual isolation from losing God. The loss of faith motif is continued when the cry for help, "oh my Lord", changes to "save yourself! help yourself!", meaning that God cannot help you until you help yourself, ie kick the drugs.

Which is really over-analyzing things I think, because really this is just what happens when Nick Cave, a complex writer fascinated by religion, writes a song about how much drug use sucks.

I did cocaine once; never again. I can definitely relate to this song, especially:

Doctor, Doctor I'm going mad This is the worst day I've ever had I can't remember Ever feeling this bad

@JohnApricot - Nick used to wake up everyday in London, go to church to purge himself of the guilt of being a drug addict. Ten he would walk down to meet his 'man' to score enough heroin (he snorted it) and amphetamine to last him the day. He would go back to his shack of a place back in those days and just do his drugs all day. Wake up, rinse and repeat the day before drug addled behavior. When he met his now wife Susie, she had one condition if she were to marry him. She said "I'll marry...

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