Lyric discussion by onequestion 

I see it more as the pervading feeling of alienation from God. "They do not know you (God) anymore." There is nothing to hold on to, no faith in the face of the realization that we must die. Jesse I believe is a biblical reference to Jesse,the father of David in the old testement. The Tree of Jesse, depicted in medieval Christian art, depicts the lineage of Jesus coming from Jesse. I believe the name is invoked here as a plea for the revival of a promise of a coming messiah, but right away there is the awareness again of separation from god, (demonic)sin, and hopelessness.

My name is Jesse, I just about died when I had this song playing in the background and I realized he was saying my name, I had to check the lyrics just to make sure I wasn't crazy! haha

@onequestion seems like the most on point interpretation I've read so far

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