Lyric discussion by LemurMaster 

It seems like there's something significant you might have missed. In the first couple verses, it's the people looking around them, asking "How could it come to this?", but in the last verse, with man on the moon, it's actually God which speaks the chorus. "I'm really worried about my creation." That makes the line, "You're really killing me, you know" all the more powerful. It's about how we have a tendency to think ourselves the center of the universe -- the most important players on the block. There's always something larger than us.

For me, it seems like it's about recognizing that humanity is NOT all there is. We look around

I always thought of that sentence taking the perspective of the man. He is pushing the boundaries of science, fixing the world's problems, and then comes "face to face with God" e.g. religion is among the world's problems. He runs into a religious or moral dilemma and it's the man calling God "my creation" instead of the other way around.

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