Lyric discussion by alphacat 

this song, pioneer to the falls, is about the brutal murder of imette st. guillen in 2006 in NYC. the pioneer was the first bar she went to with friends. she left alone and walked to the falls(another bar) at the falls she was kidnapped, raped, tortured and murdered. her body was found in the rubble of a vacant lot the next day.

This song has ambiguous lyrics, like most Interpol songs. Therefore it does not likely refer to a singular historical event.

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