Lyric discussion by swollen uvula 

As a couple people have already pointed out, I think the importance of these lyrics lies in their transparency of meaning.

For me, they remind me of when my mother passed away from cancer after a long struggle. She'd underwent chemotherapy, radiation therapy, and was, of course, on a heavy regimen of drugs.

These lyrics have a double meaning for me, however, since I was also using quite a few myself at the time to cope. In the end and as the song goes, the drugs didn't work, and that was that.

Every time I hear this song, I think of her.

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