Lyric discussion by Another_Planet 

About a Femme Fatale? But I think all the talk of her killing people is symbolic. It's more about how she slaughters the souls of her lovers when she leaves them.

And although Jeffrey Lee knows that she is this Femme Fatale character, he has to constantly remind himself about it. The heart probably tells him the opposite. ("I hate you but i love you", "If I ever close my eyes again, I'd realize what you are to me")

And in the end, he also feels sorry for her, she is "lost on the highway".

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