Lyric discussion by Prometeo 

I think that the meaning of this song is particulary relevant to Desmond's job:

You're gonna be nowhere The loneliest kind of lonely It may be rough going Just to do your thing's the hardest thing to do

Perhaps the whole library of record was carefully selected by Dharma's psicologists to encourage and motivate the hatch crew, to keep pushing the button.

On the other hand, it may refer to the big picture. I have this theory that the Dharma initiative where trying to influence, manipulate reality, either through genetics manipulation, electromagnetism, psichology, etc. (remember the "history" part on the orientation video). If this is it's meaning, it may refer to " Do not conform with the way the world is. Go out and change it ! ".

The numbers: 4, 8, 15, 16, 23, 42, may be the constants they're hoping to change... the result to some equations. When they enter them into the computer, it runs them through the system, and checks if the results have changed... like adding 2 plus 3 gets 5 everytime... but if you're able to change mathematics themselves, maybe it would sum 6, or 4.

Anyway, just a thought.

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