Lyric discussion by GratefulDylan 

Here's my interpretation:

"I did a sick, sick thing to my love My lack of loyalty, it swallowed her up And she cooked me food She squirmed and turned Like a skeleton key"

The guy telling the story had a girlfriend. She's the kind of girl who moves from one guy to another losing interest when she gets them hooked. The narrator doesn't show her that she's important to him. So she does things for him like cooking him food even though it's outside of her nature and she'd rather be moving on to someone else because he has her hooked. That's what the skeleton key part is about she likes to open every door like the key.

"She left her man and attended to me And don't call me that Don't claim you love me Cause you know that ain't true"

She left the guy she was with to get with the narrator, but he knows how she really is so he tells her not to call him her man or claim that she loves him because he knows that it's all just infatuation over the unobtainable.

"My dire affliction I'll attribute to you And you're finally free To twist and turn Like a skeleton key"

The problem is that he really does love her, but he knows how she really is so he breaks up with her so she can go back to her normal routine before he gets in too deep and she loses interest first.

"I did a horrible thing to that girl I bread my misery and drowned it in her And she got me high And I hardly noticed there were tears in her eyes"

He could drown his problems in her and she made him happy, but he couldn't get over the fact of how he knows her to really be, so he doesn't even notice her tears because he believes that her heartache is all a front.

"And I miss you less and less everyday This stream of whisky's helped to wash you away And it's clear to see You're nothing special You're a skeleton key"

He knows he's better off with out her because once he had let his guard down with her she would have left, but he's still in love with her so he drinks to take the pain away.

I think the "gotta let me know" part is about him wanting her to show him through her actions that she really was the same person so he could feel like he did the right thing by breaking up with her.

That's what it means to me because I had this same situation happen to me, just my two cents.

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