Lyric discussion by qwepoi 

Ketamine, a dissociative psychedelic drug, puts the user in a dissociated state, meaning that they are less connected to both a sense of self and the reality around them. If a large enough amount is taken the user may go into or through a "K-hole", a state of wildly dissociated experience in which other worlds or dimensions that are difficult to describe with language are said to be perceived, all the while being completely unaware of one's individual identity or the outside world

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