Lyric discussion by bittersweetwillow 

i think its about being alone in a new place, and hes talking about being unwanted, "women seem wicked when you're unwanted" cuz its so depressing and u have to feel it to kno what it feels like, u cant just say it, he did pretty good tho, so i dont think it was just a bad trip

I would go with this. I think part of it is an interpretation of calling those we don't know strangers. Like the first line says, if everyone's a stranger then they're strange. It seems like it's noting how isolated and alone one feels when they don't know anyone, when they're alone and depressed about it. It seems like no one acknowledges you or cares about you, though it may be that you're just as strange to them as they are to you.

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