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U2 – With or Without You Lyrics 15 years ago
I am so passionate about what I think this means so me. The chorus especially... I'll admit this may not apply to the verses, but anyway.. I am always reminded of a scripture passage in Mark 8:

"And [Jesus] called to him the multitude with his disciples, and said to them, 'If any man would come after me, let him deny himself and take up his cross and follow me. For whoever would save his life will lose it; and whoever loses his life for my sake and the gospel's will save it. For what does it profit a man, to gain the whole world and forfeit his life?'"

I interpret the chorus in reference with these verses. It's like Bono knows he can't live the life Jesus calls him to when he's living in the world. And Bono can't live his fleshly, sin-desiring life with God.
*So Bono can't live (fleshly) WITH Jesus (" with you"), and he can't live (for eternity, abundantly, and with hope) WITHOUT Jesus.

* This information can be up to 15 minutes delayed.